Out of every GLP‑1 supplement we reviewed, GL-ME™ was clearly different. From the very first week of testing, it left the other supplements in the dust.

Our reviewers consistently reported feeling fuller after smaller meals, more energetic throughout the day, and far more in control of themselves around snacks. As the weeks went on, many began to visibly lose weight.

And it all happened without any considerable effort on their part. Just take 2 capsules and go on about your day. Multiple testers described this experience as "life-changing."

And most telling of all... most of our testers continued using the supplement after the test period was over. This wasn't true for any other supplement on the list. Only GL-ME™.

The difference came down to more than just ingredient count — GL-ME's formula is carefully balanced, backed by a mountain of research, and delivered in a way that keeps it working for hours.

In short: If you want the supplement that checks every box for effectiveness, safety, and ease of use, GL-ME™ is the clear winner.

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Why it’s #1

Balanced, synergistic formula — Includes berberine, prebiotics, probiotics, green tea EGCG, cinnamon, and bitter melon. All these ingredients combine to create optimum conditions for natural GLP-1 production and healthy metabolic balance

Prebiotics & probiotics — Most GLP-1 supplements completely miss this crucial combination — yet it’s the most studied, science-backed way to naturally boost GLP-1. GL-ME includes both, supporting the gut bacteria directly responsible for GLP-1 release, appetite control, and smoother digestion.

Metabolism support — GL-ME combines compounds shown in research to influence key metabolic regulators such as AMPK and insulin sensitivity. This helps the body burn stored fat more effectively and maintain a healthier, more efficient metabolism over time.

Full transparency — Every ingredient and dose is clearly listed. It is professionally formulated and manufactured under strict quality standards from start to finish

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Our experience: Testers reported calmer cravings within the first week, more stable energy, and noticeably better control around snacks. Over several weeks, clothes fit looser and the “food noise” in their heads was quieter.

Bottom line: GL-ME™ offers the strongest combination of the right ingredients, in the right balance. And the results show it. GL-ME™ GLP-1 Booster is the clear winner, hands down.

Special Offer: GL-ME™ Is Offering Up to 50% OFF for Our Readers (Limited Supply)

ColonBroom has gained popularity for its clean, plant-forward formula and focus on digestion and appetite regulation. It includes ingredients like berberine, L-glutamine, and hibiscus, which have been linked to gut health, metabolism, and appetite control. Most users notice lighter digestion and reduced bloating within the first few weeks.

However, ColonBroom lacks prebiotics and probiotics, two of the most researched components for supporting GLP-1 production. It also doesn’t include any direct metabolic activators beyond berberine, meaning results may be more subtle compared to multi-pathway formulas like GL-ME.

It also includes L-glutamine, which is beneficial for overall digestive function and nutrient absorption — a strong addition — but a surprising choice was to combine it with bupleurum and hibiscus, as this trio can occasionally cause mild digestive discomfort in sensitive users. This isn’t a major concern for most, but it’s worth noting for those prone to stomach sensitivity.

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Verdict: A clean, well-rounded option for basic digestive health and mild appetite support. It includes credible ingredients like berberine and L-glutamine, but without prebiotics, probiotics, or advanced metabolic activators, it falls short of the full GLP-1 and metabolism support seen in more complete formulas like GL-ME™.

HUM has built a strong reputation for promoting digestive comfort and reducing bloating. Its formula combines a broad enzyme blend that helps break down proteins, fats, and carbohydrates, along with soothing botanicals like ginger, fennel, and peppermint to support smoother digestion and post-meal comfort. Many users notice a less bloated feeling within the first few weeks — a clear sign it’s doing its job on the digestive front.

That said, HUM isn’t designed to target GLP-1 activity or metabolism directly. It doesn’t include key GLP-1–linked ingredients such as berberine, prebiotics, or probiotics, so its effects stay focused on digestion rather than hunger control or metabolic balance.

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Verdict: A solid pick for easing bloating and supporting digestion, but not designed for those looking to influence GLP-1 or metabolic activity.

Inno Shred is built for fast metabolic activation and energy support. It includes berberine, chromium, and InnoSlim® (ginseng + astragalus) for glucose control, alongside caffeine and theobromine for a strong energy boost. Many users feel more active and focused soon after taking it.

However, it’s more of a stimulant-driven formula than a true GLP-1 support supplement. It lacks prebiotics and probiotics, so appetite and hormone balance aren’t its main strengths.

Because it’s caffeine-heavy, some users may experience jitters or restlessness, though this depends on individual tolerance.

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Verdict: A solid choice for those prioritizing energy and metabolic support. Inno Shred delivers quick, noticeable effects through its stimulant blend, but since it doesn’t target GLP-1 or gut health, it’s better viewed as a short-term metabolism and energy enhancer rather than a complete appetite or hormonal balance solution.

Lemme GLP-1 Daily takes a minimalist approach, using a trio of fruit and botanical extracts aimed at supporting appetite control and metabolic balance. The formula features Morosil™ red orange extract, Eriomin® lemon extract, and Supresa® saffron, each backed by emerging research on mood, satiety, and metabolic health. Users often describe feeling calmer around food and noticing smaller portion sizes within the first few weeks.

However, it’s a light, lifestyle-oriented formula, not a full-spectrum GLP-1 support supplement. It lacks core metabolic and gut-health ingredients such as berberine, prebiotics, and probiotics — so while it may help reduce cravings, it’s less likely to influence long-term GLP-1 activity or metabolism on its own.

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Verdict: A clean, easy-to-take option for gentle appetite and mood support, though it lacks the metabolic depth of more complete GLP-1 formulas.